******************************************************************************
*                                                                            *
*                                 TP-PHARM.ZIP                               *
*                                                                            *
*                   TURBO PASCAL PHARMACOKINETICS LIBRARY                    *
*                       Last updated : September 1998                        *
*                                                                            *
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                            AUTHOR : Dr Jean DEBORD

               Laboratoire de Pharmacologie, Faculte de Medecine
               2 Rue du Docteur Marcland, 87025 Limoges (France)
                            CompuServe : 100412,1707
                     Internet : 100412.1707@compuserve.com
               http://ourworld.compuserve.com/homepages/JDebord


******************************************************************************
 This library is distributed as freeware. You may use it any way you like,
 as long as you don't charge money for it, remove the copyright notices, 
 or hold anyone liable for its results.
******************************************************************************



CONTENTS
========

Unit
----

  PHARMAC.PAS  : Pharmacokinetics procedures and functions

Demo programs
-------------

  TESTCOEF.PAS : Computes coefficients and exponents of a multi-exponential
                 equation from model and administration parameters
  TESTCONC.PAS : Computes the plasma concentration at given times
                 from model and administration parameters
  WLS.PAS      : Fits a pharmacokinetic model by weighted least squares
  BAYES.PAS    : Fits a pharmacokinetic model by Bayesian estimation

Data files (from ref. 6)
------------------------

  HDMTX.DAT    : Data for high dose methotrexate infusion
  HDMTX2.POP   : Population parameters for high dose methotrexate infusion
                 (2 compartments)
  HDMTX3.POP   : Population parameters for high dose methotrexate infusion
                 (3 compartments)

Documentation file
------------------

  TP-PHARM.TXT : This file

The use of the programs is explained in the comment part of each file.


SYSTEM REQUIREMENTS
===================

PC or compatible
Math coprocessor recommended
Turbo Pascal v. 5.0 or higher
TPMATH1.ZIP installed


INSTALLATION
============

- Copy all the files to a given directory
- The units contained in TPMATH1.ZIP must be installed in a directory
  accessible to Turbo Pascal


REFERENCES
==========

(1) D. BOURNE
    Mathematical Modeling of Pharmacokinetic Data
    Technomic 1995

(2) M. GIBALDI & D. PERRIER
    Pharmacokinetics, 2nd edition
    Dekker 1982

(3) R. GOMENI & C. GOMENI
    Automod : A polyalgorithm for an integrated analysis of linear
    pharmacokinetic models
    Comput. Biol. Med., 1979, 9, 39-48

(4) A. ILIADIS, R. BRUNO & J. P. CANO
    Steady-state dosage regimen calculations in linear pharmacokinetics
    Int. J. Bio-Medical Computing, 1986, 18, 167-182

(5) J. A. NELDER & R. MEAD
    A simplex method for function minimization.
    Comput. J., 1964, 7, 308-313

(6) C. SABOT, J. DEBORD, B. ROULLET et al
    Comparison of 2- and 3-compartment models for the Bayesian estimation
    of methotrexate pharmacokinetics
    Int. J. Clin. Pharmacol. Therap., 1995, 32, 164-169

