******************************************************************************
*                                                                            *
*                                 TP-GLS.ZIP                                 *
*                                                                            *
*              TURBO PASCAL GENERALIZED LEAST SQUARES PROGRAM                *
*                       Last updated : September 1998                        *
*                                                                            *
******************************************************************************



                     AUTHORS : Jean DEBORD & Karine SUCHAUD

               Laboratoire de Pharmacologie, Faculte de Medecine
               2 Rue du Docteur Marcland, 87025 Limoges (France)
                            CompuServe : 100412,1707
                       Internet : JDebord@compuserve.com
               http://ourworld.compuserve.com/homepages/JDebord


******************************************************************************
 This program is distributed as freeware. You may use it any way you like,
 as long as you don't charge money for it, remove the copyright notices,
 or hold anyone liable for its results.
******************************************************************************



CONTENTS
========

Program
-------

  GLS.PAS      : Generalized least squares fitting program

Data file
---------

  ARYL.DAT     : Sample data from the authors' laboratory
                 (Activity of the serum enzyme arylesterase in 7 subjects
                 as a function of substrate concentration)

Documentation file
------------------

  TP-GLS.TXT   : This file

The use of the program is explained in the comment part of the GLS.PAS file.


SYSTEM REQUIREMENTS
===================

PC or compatible
Math coprocessor recommended
Turbo Pascal v. 5.0 or higher
TPMATH1.ZIP installed


INSTALLATION
============

- Copy all the files to a given directory
- The units contained in TPMATH1.ZIP must be installed in a directory
  accessible to Turbo Pascal


REFERENCES
==========

(1) M. DAVIDIAN & D. M. GILTINAN
    Some simple methods for estimating intraindividual variability
    in nonlinear mixed effects models.
    Biometrics, 1993, 49, 59-73

(2) J. A. NELDER & R. MEAD
    A simplex method for function minimization.
    Comput. J., 1964, 7, 308-313

